Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs.

Xiaoyun Chen, Sijia Fan, Chunchun Zhu, Qian Liao, Jinhua Tang, Guangqing Yu, Xiaolian Cai, Gang Ouyang, Wuhan Xiao, Xing Liu

Journal of immunology (Baltimore, Md. : 1950) 2022 Sep 15

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The signaling adaptor MAVS is a critical determinant in retinoic acid-inducible gene 1-like receptor signaling, and its activation is tightly controlled by multiple mechanisms in response to viral infection, including phosphorylation and ubiquitination. In this article, we demonstrate that zebrafish sirt5, one of the sirtuin family proteins, negatively regulates mavs-mediated antiviral innate immunity. Sirt5 is induced by spring viremia of carp virus (SVCV) infection and binds to mavs, resulting in attenuating phosphorylation and ubiquitination of mavs. Disruption of sirt5 in zebrafish promotes survival ratio after challenge with SVCV. Consistently, the antiviral responsive genes are enhanced, and the replication of SVCV is diminished in sirt5-dificient zebrafish. Therefore, we reveal a function of zebrafish sirt5 in the negative regulation of antiviral innate immunity by targeting mavs. Copyright © 2022 by The American Association of Immunologists, Inc.

Citation

Xiaoyun Chen, Sijia Fan, Chunchun Zhu, Qian Liao, Jinhua Tang, Guangqing Yu, Xiaolian Cai, Gang Ouyang, Wuhan Xiao, Xing Liu. Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs. Journal of immunology (Baltimore, Md. : 1950). 2022 Sep 15;209(6):1165-1172