Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking.

Chayanika Gundu, Vijay Kumar Arruri, Poonam Yadav, Umashanker Navik, Ashutosh Kumar, Veda Sudhir Amalkar, Ajit Vikram, Ravinder Reddy Gaddam

Cells 2022 Aug 17

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Endocytosis is a fundamental mechanism by which cells perform housekeeping functions. It occurs via a variety of mechanisms and involves many regulatory proteins. The GTPase dynamin acts as a "molecular scissor" to form endocytic vesicles and is a critical regulator among the proteins involved in endocytosis. Some GTPases (e.g., Cdc42, arf6, RhoA), membrane proteins (e.g., flotillins, tetraspanins), and secondary messengers (e.g., calcium) mediate dynamin-independent endocytosis. These pathways may be convergent, as multiple pathways exist in a single cell. However, what determines the specific path of endocytosis is complex and challenging to comprehend. This review summarizes the mechanisms of dynamin-independent endocytosis, the involvement of microRNAs, and factors that contribute to the cellular decision about the specific route of endocytosis.

Citation

Chayanika Gundu, Vijay Kumar Arruri, Poonam Yadav, Umashanker Navik, Ashutosh Kumar, Veda Sudhir Amalkar, Ajit Vikram, Ravinder Reddy Gaddam. Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking. Cells. 2022 Aug 17;11(16)