Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides.

Molecules (Basel, Switzerland) 2022 Aug 10

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New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48-88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73-95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.

Citation

Denis V Sudarikov, Yulia V Gyrdymova, Alexander V Borisov, Julia M Lukiyanova, Roman V Rumyantcev, Oksana G Shevchenko, Diana R Baidamshina, Nargiza D Zakarova, Airat R Kayumov, Ekaterina O Sinegubova, Alexandrina S Volobueva, Vladimir V Zarubaev, Svetlana A Rubtsova. Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides. Molecules (Basel, Switzerland). 2022 Aug 10;27(16)