The Role of Leukocyte Immunoglobulin-Like Receptors Focusing on the Therapeutic Implications of the Subfamily B2.

Yanyu Hu, Xin Lu, Weimin Qiu, Hui Liu, Qinghua Wang, Yao Chen, Wenyuan Liu, Feng Feng, Haopeng Sun

Current drug targets 2022

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The leukocyte immunoglobulin (Ig)-like receptors (LILRs) are constituted by five inhibitory subpopulations (LILRB1-5) and six stimulatory subpopulations (LILRA1-6). The LILR populations substantially reside in immune cells, especially myeloid cells, functioning as a regulator in immunosuppressive and immunostimulatory responses, during which the nonclassical major histocompatibility complex (MHC) class I molecules are widely involved. In addition, LILRs are also distributed in certain tumor cells, implicated in the malignancy progression. Collectively, the suppressive Ig-like LILRB2 is relatively well-studied to date. Herein, we summarized the whole family of LILRs and their biologic function in various diseases upon ligation to the critical ligands, therefore providing more information on their potential roles in these pathological processes and giving the clinical significance of strategies targeting LILRs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Yanyu Hu, Xin Lu, Weimin Qiu, Hui Liu, Qinghua Wang, Yao Chen, Wenyuan Liu, Feng Feng, Haopeng Sun. The Role of Leukocyte Immunoglobulin-Like Receptors Focusing on the Therapeutic Implications of the Subfamily B2. Current drug targets. 2022;23(15):1430-1452