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Enantioselective Nickel-Catalyzed C(sp3 )-H Activation of Formamides.
Yin-Xia Wang, Feng-Ping Zhang, Hao Chen, Yue Li, Jiang-Fei Li, Mengchun Ye
Angewandte Chemie (International ed. in English) 2022 Oct 17Sizes of these terms reflect their relevance to your search.
Enantioselective Ni-catalyzed C(sp3 )-H bond activation remains an elusive challenge. Herein, we used phosphine oxide-ligated Ni-Al bimetallic catalyst to realize enantioselective Ni-catalyzed aliphatic C(sp3 )-H activation of formamides, providing a series of chiral N-containing heterocycles in 40-95 % yield and 70-95 % ee. © 2022 Wiley-VCH GmbH.
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Yin-Xia Wang, Feng-Ping Zhang, Hao Chen, Yue Li, Jiang-Fei Li, Mengchun Ye. Enantioselective Nickel-Catalyzed C(sp3 )-H Activation of Formamides. Angewandte Chemie (International ed. in English). 2022 Oct 17;61(42):e202209625
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PMID: 36036435
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