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The sartans are a new class of antihypertensive drugs as angiotensin II receptor blockers which possess plenty of ad-vantages in treating hypertension and related pathologies. This review describes the clinical treatment, side effects, and po-tential therapeutic effects of sartans from 1995 to date. The synthesis, structural-activity and molecular docking with Angi-otensin Type 1 receptor of imidazole derivatives, benzimidazole derivatives and other compounds are also described. With clear Structure-Activity Relationship and abundant pharmacological effects, some types of novel Angiotensin Type 1 re-ceptor antagonists are emerging gradually for further research in the meantime.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Ye-Fan Wang, Xin-Yue Ren, Wen Zhang, Guo-Wu Rao. Research Progress in Pharmacological Mechanisms, Structure-Activity Relationship and Synthesis of Sartans. Current medicinal chemistry. 2022 Aug 29


PMID: 36043743

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