Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision.

Oxidative medicine and cellular longevity 2022

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A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration's extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI. Copyright © 2022 Fahadul Islam et al.

Citation

Fahadul Islam, Sristy Bepary, Mohamed H Nafady, Md Rezaul Islam, Talha Bin Emran, Sharifa Sultana, Md Amdadul Huq, Saikat Mitra, Hitesh Chopra, Rohit Sharma, Sherouk Hussein Sweilam, Mayeen Uddin Khandaker, Abubakr M Idris. Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision. Oxidative medicine and cellular longevity. 2022;2022:8741787