Bin Mao, Zhi-Wei Chen, Jian-Fei Wang, Chao-Huan Zhang, Zhi-Qian Du, Chuan-Ming Yu
Organic letters 2022 Sep 16The enantioselective organocatalytic conjugate alkenylation of β-substituted alkenyl benzimidazoles afforded β-stereogenic 2-alkyl benzimidazole derivatives in excellent enantioselectivities. Chiral binaphthols were effective catalysts for promoting the nucleophilic addition of bench-stable alkenyl trifluoroborate salts under mild conditions, expanding their applications by utilizing C=N-containing azaarenes as activating groups. The synthetic utility of this strategy is demonstrated by conversions into several useful enantiomerically enriched benzimidazole building blocks.
Bin Mao, Zhi-Wei Chen, Jian-Fei Wang, Chao-Huan Zhang, Zhi-Qian Du, Chuan-Ming Yu. Enantioselective Conjugate Addition of Alkenyl Trifluoroborates to Alkenyl-Substituted Benzimidazoles Catalyzed by Chiral Binaphthols. Organic letters. 2022 Sep 16;24(36):6588-6593
PMID: 36053071
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