Cryo-EM structure of human MG53 homodimer.

Yange Niu, Gengjia Chen, Fengxiang Lv, Rui-Ping Xiao, Xinli Hu, Lei Chen

The Biochemical journal 2022 Sep 16

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MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a 'body' and two 'wings'. Intermolecular interactions are mainly distributed in the 'body' which is relatively stable, while two 'wings' are more dynamic. The overall architecture of MG53 is distinct from those of TRIM20 and TRIM25, illustrating the broad structural diversity of this protein family. © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Citation

Yange Niu, Gengjia Chen, Fengxiang Lv, Rui-Ping Xiao, Xinli Hu, Lei Chen. Cryo-EM structure of human MG53 homodimer. The Biochemical journal. 2022 Sep 16;479(17):1909-1916