Airway Smooth Muscles Contractions in Metabolic Syndrome.

Yu G Birulina, V V Ivanov, E E Buiko, A N Dzyuman, A V Nosarev, O V Voronkova, M O Vol'khina, S V Gusakova

Bulletin of experimental biology and medicine 2022 Aug

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We studied contractile responses of isolated airway smooth muscle segments from rats with metabolic syndrome. Metabolic syndrome was induced in rats by high-fat and high-carbohydrate diet. It was shown that metabolic syndrome was associated with an increase of bronchoconstrictor action of cholinergic receptor activator carbacholine (0.1-100 μM) and a decrease of the dilatory effect of β2-adrenoreceptor activator salbutamol (0.1-100 μM). The observed effects of agonists are epithelium-dependent. Disorders in contractile activity in the airway smooth muscles were accompanied by bronchial epithelium destruction, immune inflammation in the bronchial wall, muscular and peribronchial adipose tissue hypertrophy. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Citation

Yu G Birulina, V V Ivanov, E E Buiko, A N Dzyuman, A V Nosarev, O V Voronkova, M O Vol'khina, S V Gusakova. Airway Smooth Muscles Contractions in Metabolic Syndrome. Bulletin of experimental biology and medicine. 2022 Aug;173(4):486-489