Efficacy of a spot-on combination of fluralaner plus moxidectin against naturally acquired Sarcoptes scabiei infestation in 10 pet rabbits: Retrospective case series.

Dario d'Ovidio, Domenico Santoro

Veterinary dermatology 2023 Feb

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Current treatments for sarcoptic mange in rabbits mainly include administration of avermectines every 10-30 days. Recently, a single oral dose of fluralaner has been shown to be effective to treat sarcoptic mange in 12 pet rabbits over a three-month period. To retrospectively assess the efficacy of a spot-on combination of fluralaner plus moxidectin (Bravecto Plus) for the treatment of sarcoptic mange in rabbits. Ten client-owned rabbits diagnosed with sarcoptic mange. An application of fluralaner plus moxidectin at an average dose of 25 mg/kg and 1.24 mg/kg, respectively, was administered topically once. Parasitological and dermatological examination was carried out weekly for one month and monthly for three months. The median age at diagnosis was 15 (range 3-48) months. Based on the age of onset, there were three juvenile (<6-month-old) and seven adult-onset cases. Of those, four were generalized (head, feet and/or genital area) and six were localized form (head only). The combination of fluralaner plus moxidectin resulted in 100% eradication of mites and complete resolution of all skin lesions within 21 days. Recurrence was not observed 90 days post-treatment. Relapse was not observed in one case followed up for a further four months and two rabbits followed up for a further six months. The other pets were lost to follow-up. These results indicated that a single dose of a formulation containing fluralaner plus moxidectin, at 25 mg/kg and 1.24 mg/kg, respectively, was effective for the treatment of naturally occurring sarcoptic mange in rabbits. © 2022 ESVD and ACVD.

Citation

Dario d'Ovidio, Domenico Santoro. Efficacy of a spot-on combination of fluralaner plus moxidectin against naturally acquired Sarcoptes scabiei infestation in 10 pet rabbits: Retrospective case series. Veterinary dermatology. 2023 Feb;34(1):3-6