Pharmacokinetic interaction between raltegravir and rifampicin in an infant with HIV exposed to active TB: a case report.

Marlotte Aa van der Veer, Tom G Jacobs, Laura H Bukkems, Angela Ph Colbers, David M Burger, Henriette J Scherpbier, Yuma A Bijleveld

Antiviral therapy 2022 Aug

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We report a case of an infant with HIV receiving raltegravir granules for oral suspension and rifampicin-based TB prophylaxis. Raltegravir trough levels remained subtherapeutic and viral load increased during concurrent rifampicin therapy despite using double-dosed raltegravir. Even after rifampicin therapy, a higher dose was needed. This highlights the importance of therapeutic drug monitoring and dose adjustments of raltegravir in infants with rifampicin as comedication.

Citation

Marlotte Aa van der Veer, Tom G Jacobs, Laura H Bukkems, Angela Ph Colbers, David M Burger, Henriette J Scherpbier, Yuma A Bijleveld. Pharmacokinetic interaction between raltegravir and rifampicin in an infant with HIV exposed to active TB: a case report. Antiviral therapy. 2022 Aug;27(4):13596535221119932