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Clinical and epidemiological evidence indicate a relationship between thyroid diseases and melanoma. In particular, the hypothyroidism condition appears to promote melanoma spread, which suggests a protective role of thyroid hormones against disease progression. In addition, experimental data suggest that, in addition to thyroid hormones, other hormonal players of the hypothalamic-pituitary-thyroid (HPT) axis, namely the thyrotropin releasing hormone and the thyrotropin, are likely to affect melanoma cells behavior. This information warrants further clinical and experimental studies in order to build a precise pattern of action of the HPT hormones on melanoma cells. An improved knowledge of the involved molecular mechanism(s) could lead to a better and possibly personalized clinical management of these patients.


Salvatore Ulisse, Enke Baldini, Daniele Pironi, Federica Gagliardi, Domenico Tripodi, Augusto Lauro, Sabino Carbotta, Danilo Tarroni, Matteo D'Armiento, Aldo Morrone, Flavio Forte, Flaminia Frattaroli, Severino Persechino, Teresa Odorisio, Vito D'Andrea, Eleonora Lori, Salvatore Sorrenti. Is Melanoma Progression Affected by Thyroid Diseases? International journal of molecular sciences. 2022 Sep 02;23(17)

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PMID: 36077430

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