Library Synthesis and Analytics.

Jing Chai

Methods in molecular biology (Clifton, N.J.) 2022

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DNA-encoded library synthesis is an evolved combinatorial synthesis, using a split-and-pool strategy in 96-well plates, libraries containing millions to billions of compounds can be prepared by a combination of chemical and enzymatic synthesis. Here we describe the analytics methods used in the library synthesis with one cycle of synthesis as an example. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.