Intrinsically disordered proteins in viral pathogenesis and infections.

Chandrabose Selvaraj, Muthuraja Arun Pravin, Wardah A Alhoqail, Anuraj Nayarisseri, Sanjeev Kumar Singh

Advances in protein chemistry and structural biology 2022

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Disordered proteins serve a crucial part in many biological processes that go beyond the capabilities of ordered proteins. A large number of virus-encoded proteins have extremely condensed proteomes and genomes, which results in highly disordered proteins. The presence of these IDPs allows them to rapidly adapt to changes in their biological environment and play a significant role in viral replication and down-regulation of host defense mechanisms. Since viruses undergo rapid evolution and have a high rate of mutation and accumulation in their proteome, IDPs' insights into viruses are critical for understanding how viruses hijack cells and cause disease. There are many conformational changes that IDPs can adopt in order to interact with different protein partners and thus stabilize the particular fold and withstand high mutation rates. This chapter explains the molecular mechanism behind viral IDPs, as well as the significance of recent research in the field of IDPs, with the goal of gaining a deeper comprehension of the essential roles and functions played by viral proteins. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Chandrabose Selvaraj, Muthuraja Arun Pravin, Wardah A Alhoqail, Anuraj Nayarisseri, Sanjeev Kumar Singh. Intrinsically disordered proteins in viral pathogenesis and infections. Advances in protein chemistry and structural biology. 2022;132:221-242