Battle of the γδ T cell subsets in the gut.

Sofia Mensurado, Bruno Silva-Santos

Trends in cancer 2022 Nov

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In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL)-17+ γδ T cell subsets that promote its growth. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.