Immunologically "cold" triple negative breast cancers engraft at a higher rate in patient derived xenografts.

TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment. © 2022. The Author(s).

Citation

Varduhi Petrosyan, Lacey E Dobrolecki, Emily L LaPlante, Ramakrishnan Rajaram Srinivasan, Matthew H Bailey, Alana L Welm, Bryan E Welm, Michael T Lewis, Aleksandar Milosavljevic. Immunologically "cold" triple negative breast cancers engraft at a higher rate in patient derived xenografts. NPJ breast cancer. 2022 Sep 10;8(1):104

PMID: 36088362

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