Transcriptional regulation of B cell class-switch recombination: the role in development of noninfectious complications.

Stelios Vlachiotis, Hassan Abolhassani

Expert review of clinical immunology 2022 Nov

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The process of immunoglobulin class switch recombination (CSR) occurs in secondary lymphoid organs. This highly regulated process is essential for the development of different antibody isotype maturation and long-life memory/plasma cell generation. Patients with impaired CSR present heterogeneous noninfectious complications. We provide an overview of recent advancements in the tight regulation of B cells before and during the CSR at different levels of cytokine stimulations, intracellular signaling, transcription-factor activation, gene transcription, and epigenetic controls. Besides recurrent infections which result from the lack of production of class-switched immunoglobulins, intrinsic B cell signaling pathways and regulatory component defects have distinct roles in other immune-related clinical manifestations including autoimmunity, atopy, lymphoproliferation, and cancer.

Citation

Stelios Vlachiotis, Hassan Abolhassani. Transcriptional regulation of B cell class-switch recombination: the role in development of noninfectious complications. Expert review of clinical immunology. 2022 Nov;18(11):1145-1154