Sarcoeleganolides C-G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans.

Cili Wang, Jiarui Zhang, Xing Shi, Kai Li, Fengling Li, Xuli Tang, Guoqiang Li, Pinglin Li

Marine drugs 2022 Sep 10

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Five new cembranes, named sarcoeleganolides C-G (1-5), along with three known analogs (6-8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 μM.

Citation

Cili Wang, Jiarui Zhang, Xing Shi, Kai Li, Fengling Li, Xuli Tang, Guoqiang Li, Pinglin Li. Sarcoeleganolides C-G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans. Marine drugs. 2022 Sep 10;20(9)