Eosinophil Peroxidase Staining Enhances the Diagnostic Utility of the Cytosponge in Eosinophilic Esophagitis.

We aimed to assess the diagnostic utility of eosinophil peroxidase (EPX) staining on Cytosponge (CS) samples in eosinophilic esophagitis (EoE). Esophageal biopsy (BX) samples from adult subjects with EoE were assessed using peak eosinophils per high-power field (eos/hpf), EPX, and the EoE histologic scoring system. EPX staining and eos/hpf were compared (BX vs CS). CS EPX positivity correlated with eos/hpf (CS [ r = 0.82, P < 0.0001]; BX [ r = 0.65, P < 0.0001]) and EoE histologic scoring system (grade [ r = 0.62, P < 0.00001]; stage [ r = 0.61, P < 0.0001]). CS EPX identified subjects with active EoE (area under the curve = 0.86, P < 0.0001). The correlation of CS EPX with eosinophilic inflammation and histologic disease severity supports its diagnostic utility in EoE. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.

Citation

Mia Y Masuda, Suzanne M Barshow, Shipra Garg, Arina Putikova, William E LeSuer, Jeffrey A Alexander, David A Katzka, Evan S Dellon, Hirohito Kita, Jennifer L Horsley-Silva, Alfred D Doyle, Benjamin L Wright. Eosinophil Peroxidase Staining Enhances the Diagnostic Utility of the Cytosponge in Eosinophilic Esophagitis. Clinical and translational gastroenterology. 2022 Nov 01;13(11):e00534

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PMID: 36137185

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