Retroviral DNA induces the production of interferons. A new study by Yoh et al. showed that the host factor 'PQBP1' primes immune-recognition of retroviral DNA by recruiting the cytosolic DNA scavenger 'cGAS' to the HIV-1 capsid. Their findings support the importance of innate immune sensing in HIV-1 infection. Copyright © 2022 Elsevier Ltd. All rights reserved.
Citation
Nicholas Dopkins, Douglas F Nixon. Two-step recognition of HIV-1 DNA in the cytosol. Trends in microbiology. 2023 May;31(5):430-431
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PMID: 36153261
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