Formation and function of a highly specialised type of organelle in cardiac valve cells.

Christian Meyer, Leonhard Breitsprecher, Laetitia Bataille, Alain J M Vincent, Maik Drechsler, Heiko Meyer, Achim Paululat

Development (Cambridge, England) 2022 Oct 01

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Within a cell, vesicles play a crucial role in the transport of membrane material and proteins to a given target membrane, and thus regulate a variety of cellular functions. Vesicular transport occurs by means of, among others, endocytosis, where cargoes are taken up by the cell and are processed further upon vesicular trafficking, i.e. transported back to the plasma membrane via recycling endosomes or the degraded by fusion of the vesicles with lysosomes. During evolution, a variety of vesicles with individual functions arose, with some of them building up highly specialised subcellular compartments. In this study, we have analysed the biosynthesis of a new vesicular compartment present in the valve cells of Drosophila melanogaster. We show that the compartment is formed by invaginations of the plasma membrane and grows via re-routing of the recycling endosomal pathway. This is achieved by inactivation of other membrane-consuming pathways and a plasma membrane-like molecular signature of the compartment in these highly specialised heart cells. © 2022. Published by The Company of Biologists Ltd.

Citation

Christian Meyer, Leonhard Breitsprecher, Laetitia Bataille, Alain J M Vincent, Maik Drechsler, Heiko Meyer, Achim Paululat. Formation and function of a highly specialised type of organelle in cardiac valve cells. Development (Cambridge, England). 2022 Oct 01;149(19)