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GOT2: An Unexpected Mediator of Immunosuppression in Pancreatic Cancer.
Cancer discovery 2022 Oct 05Sizes of these terms reflect their relevance to your search.
In this issue, Abrego and colleagues describe an unexpected role for the mitochondrial enzyme glutamic-oxaloacetic transaminase (GOT2) in pancreatic cancer, whereby it acts as a nuclear fatty acid transporter binding to and activating the PPARδ nuclear receptor. In turn, the GOT2-PPARδaxis drives immunosuppression by suppressing T cell-mediated antitumor immunity. See related article by Abrego et al., p. 2414 (3). ©2022 American Association for Cancer Research.
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Zeribe C Nwosu, Marina Pasca di Magliano. GOT2: An Unexpected Mediator of Immunosuppression in Pancreatic Cancer. Cancer discovery. 2022 Oct 05;12(10):2237-2239
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PMID: 36196574
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