Apolipoprotein-mimetic Peptides: Current and Future Prospectives.

Apolipoprotein-mimetic peptides, mimicking the biological properties of apolipoproteins, have shown beneficial properties against various diseases (central and peripheral diseases) and have emerged as potential candidates for their treatments. Progress has been made from first-generation to second-generation apolipoprotein-mimetic peptides. Understanding these peptides from the first generation to the second generation is discussed in this review. First, we discussed the structural and therapeutic potentials of first-generation apolipoprotein-mimetic peptides. Further, we discussed the development of second-generation apolipoprotein-mimetic peptides, like dual-domain and bihelical peptides the emergence of second-generation apolipoprotein-mimetic peptides as potential candidates in different preclinical and clinical studies has also been emphasized. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Sunil A Nankar, Sakeel Ahmed, Shyam Sunder Sharma, Abhay H Pande. Apolipoprotein-mimetic Peptides: Current and Future Prospectives. Current protein & peptide science. 2022;23(11):757-772

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PMID: 36200201

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