Falsely Elevated Estradiol Results in a 62-Year-Old Male Patient.

Gergely Talaber, Tomas Meisel, Thord Rosen

Laboratory medicine 2023 Jul 05

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Falsely increased estradiol levels can lead to unnecessary tests and therapeutic interventions. Here, we present a case of a 62-year-old man with falsely elevated estradiol, which led to subsequent follow-up testing and prescriptions. Alternative immunoassay testing, in conjunction with Scantibodies' blocking reagents, polyethylene glycol precipitation, and liquid chromatography-tandem mass spectrometry confirmation demonstrated that the falsely elevated estradiol was due to the presence of macro-estradiol. This report emphasizes the importance of recognizing analytical interferences in immunoassays to appropriately manage subsequent testing and patient care. © The Author(s) 2022. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Citation

Gergely Talaber, Tomas Meisel, Thord Rosen. Falsely Elevated Estradiol Results in a 62-Year-Old Male Patient. Laboratory medicine. 2023 Jul 05;54(4):e111-e113