Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation.

ASAIO journal (American Society for Artificial Internal Organs : 1992) 2022 Nov 01

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The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory status in nine subjects implanted with the A-TAH in kinetics over one year. Laboratory assessment of leukocyte counts, inflammatory cytokines assay, and peripheral blood mononuclear cell collection before and after A-TAH implantation. Leukocyte counts were not significantly modulated according to time after A-TAH implantation (coefficient of the linear mixed effect model with 95% CI, -0.05 (-0.71 to -0.61); p = 0.44). We explored inflammatory cytokine after A-TAH and did not observe, at any time, a modified profile compared to pre-implantation values (all p -values > 0.05). Finally, we compared the distribution of circulating immune cell subpopulations identified based on sequential expression patterns for multiple clusters of differentiation. None of the population explored had significant modulation during the 12-month follow-up (all p -values > 0.05). In conclusion, using a cytokine multiplex assay combined with a flow cytometry approach, we demonstrated the absence of inflammatory signals in peripheral blood over a period of 12 months following A-TAH implantation. Copyright © ASAIO 2022.

Citation

Christophe Peronino, Coralie L Guerin, Peter Ivak, Léa Guyonnet, Richard Chocron, Grégoire Detriché, Christian Latremouille, Maxime Gruest, Aurélien Philippe, Antoine Capel, Yuri Pya, Anne-Céline Martin, Piet Jansen, Nicolas Gendron, Ivan Netuka, David M Smadja. Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2022 Nov 01;68(11):e173-e178