From Peptide Nucleic Acids to Supramolecular Structures of Nucleic Acid Derivatives.

Lajos Kovács

Chemical record (New York, N.Y.) 2023 Jan

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Nucleic acids play a pivotal role in life processes. The endeavours to shed light on the essential properties of these intriguing building blocks led us to the synthesis of different analogues and the investigation of their properties. First various peptide nucleic acid monomers and oligomers have been synthesized, using an Fmoc/acyl protecting group strategy, and their properties studied. The serendipitous discovery of a side reaction of coupling agents led us to the elaboration of a peptide sequencing method. The capricious behaviour of guanine derivatives spurred the determination of their substitution pattern using 13 C, 15 N NMR, and mass spectrometric methods. The properties of guanines initiated the logical transition to the study of supramolecular systems composed of purine analogues. Thus, xanthine and uracil derivatives have been obtained and their supramolecular self-assembly properties scrutinized in gas, solid, and liquid states and at solid-liquid interfaces. © 2022 The Authors. The Chemical Record published by The Chemical Society of Japan and Wiley-VCH GmbH.

Citation

Lajos Kovács. From Peptide Nucleic Acids to Supramolecular Structures of Nucleic Acid Derivatives. Chemical record (New York, N.Y.). 2023 Jan;23(1):e202200203