Correlation Engine 2.0
Clear Search sequence regions


  • 1 receptor (1)
  • antigen (1)
  • CSF 1R (4)
  • CSF- 1 (4)
  • cytokines (3)
  • hematopoiesis (1)
  • homeostasis (1)
  • M- CSF (3)
  • macrophages (12)
  • myelopoiesis (1)
  • phenotypes (3)
  • signal (1)
  • Sizes of these terms reflect their relevance to your search.

    Macrophages are one of the first innate immune cells to reach the site of infection or injury. Diverse functions from the uptake of pathogen or antigen, its killing, and presentation, the release of pro- or anti-inflammatory cytokines, activation of adaptive immune cells, clearing off tissue debris, tissue repair, and maintenance of tissue homeostasis have been attributed to macrophages. Besides tissue-resident macrophages, the circulating macrophages are recruited to different tissues to get activated. These are highly plastic cells, showing a spectrum of phenotypes depending on the stimulus received from their immediate environment. The macrophage differentiation requires colony-stimulating factor-1 (CSF-1) or macrophage colony-stimulating factor (M-CSF), colony-stimulating factor-2 (CSF-2), or granulocyte-macrophage colony-stimulating factor (GM-CSF) and different stimuli activate them to different phenotypes. The richness of tissue macrophages is precisely controlled via the CSF-1 and CSF-1R axis. In this review, we have given an overview of macrophage origin via hematopoiesis/myelopoiesis, different phenotypes associated with macrophages, their clinical significance, and how they are altered in various diseases. We have specifically focused on the function of CSF-1/CSF-1R signaling in deciding macrophage fate and the outcome of aberrant CSF-1R signaling in relation to macrophage phenotype in different diseases. We further extend the review to briefly discuss the possible strategies to manipulate CSF-1R and its signaling with the recent updates. © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

    Citation

    Shivani Yadav, Astik Priya, Diksha R Borade, Reena Agrawal-Rajput. Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance. Immunologic research. 2023 Apr;71(2):130-152

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 36266603

    View Full Text