Inhibiting Sublimation of Thymol by Cocrystallization.

Hui Zu, Rodger F Henry, Geoff G Z Zhang, Leonard R MacGillivray

Journal of pharmaceutical sciences 2023 Jan

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A thymol:4,4'-dipyridyl (2:1) cocrystal (Form I) is reported to suppress thymol sublimation. The cocrystal was prepared via solution-mediated phase transformation and its structure is sustained by O-H (phenol) ··· N (pyridyl) hydrogen bonds between two individual components. A cocrystal polymorph (Form II) was formed via solid state transformation or via vapor phase upon heating. Using gravimetry analysis, it was demonstrated that cocrystal Form I decreased the sublimation rate of thymol by 38-fold. This study demonstrates that cocrystallization is an effective approach to reduce vapor pressure and sublimation of solids, thus achieving odor-masking. Copyright © 2022. Published by Elsevier Inc.

Citation

Hui Zu, Rodger F Henry, Geoff G Z Zhang, Leonard R MacGillivray. Inhibiting Sublimation of Thymol by Cocrystallization. Journal of pharmaceutical sciences. 2023 Jan;112(1):350-353