Use of asprosin and subfatin for differential diagnosis of serous ovarian tumors.

Miyase Mirzaoglu, Seyda Yavuzkir, Cetin Mirzaoglu, Nurdan Yurt, Adile Ferda Dagli, Sena Ozcan Yildirim, İbrahim Sahin, Suleyman Aydin

Biotechnic & histochemistry : official publication of the Biological Stain Commission 2023 Feb

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Asprosin (ASP) and subfatin are hormones that regulate glucose metabolism. The role of ASP and subfatin in serous ovarian tumors has not been investigated. We investigated the expression of subfatin and asprosin in 30 serous benign, 30 serous borderline, 30 malignant and 30 control ovarian tissues. We investigated ASP and subfatin immunoreactivity and quantification was achieved using an ELISA method. ASP and subfatin were localized in the epithelial parts of normal ovarian tissues; however, in cancer tissues, immunoreactivity was detected in the parenchymal areas. Biochemical analysis of ovarian tissues revealed significantly decreased ASP and subfatin compared to the control. We propose that ASP and subfatin are promising candidates for biomarkers to distinguish serous benign, serous borderline and malignant ovarian cancers.

Citation

Miyase Mirzaoglu, Seyda Yavuzkir, Cetin Mirzaoglu, Nurdan Yurt, Adile Ferda Dagli, Sena Ozcan Yildirim, İbrahim Sahin, Suleyman Aydin. Use of asprosin and subfatin for differential diagnosis of serous ovarian tumors. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023 Feb;98(2):140-146