Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Acute pancreatitis (AP) is a common inflammatory disease of the digestive system. Mitochondrial calcium uniporter (MCU) mediates mitochondrial uptake of Ca2+ and plays an important role in calcium homeostasis. However, it is undefined whether AP can be relieved by inhibiting MCU. This study aimed to study the therapeutic potential of Ruthenium red (RuR), a MCU inhibitor, in AP mice model and primary acinar cells. Cell injury and AP mice model was induced by caerulein. RuR alleviated CER-AP evidenced by reduced serum lipase, TNF-α, and pancreatic MPO levels, less severe pancreatic pathology damage, and decreased inflammatory cell infiltration. In freshly isolated pancreatic acinar cells, RuR diminished cell necrosis with effect on suppressing the expression of MCU. RuR also decreased levels of cytosolic calcium and ROS, preventing mitochondrial membrane potential loss, ATP depletion and MPTP opening. The present findings indicate that inhibit MCU by RuR has a beneficial effect in AP by preventing calcium overload, mitochondrial dysfunction, and cell necrosis. Copyright © 2022 Elsevier Inc. All rights reserved.


Xiuyan Yu, Chen Dai, Xuemin Zhao, Qiuyang Huang, Xuelian He, Rui Zhang, Zhihua Lin, Yan Shen. Ruthenium red attenuates acute pancreatitis by inhibiting MCU and improving mitochondrial function. Biochemical and biophysical research communications. 2022 Dec 20;635:236-243

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 36283336

View Full Text