Four new compounds from the fruits of Chinese dwarf cherry (Prunus humilis Bunge).

Sheng Dong, Ying Zhou, Ji-Chao Wang, Yi-Lin Zhuo, Yi-Han Sun, Jun-Gang Wang, Guo-Gang Zhang

Natural product research 2024 Apr

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A new flavonoid (bunge A) (1), a new sesquiterpene (bunge B) (8), a new furan derivative (bunge C) (12) and a new alkenoic acid (bunge D) (14), together with ten known ones [four flavonoids (2, 3, 4, 5), two phenylpropanoids (6, 7), three sesquiterpenes (9, 10, 11) and one lactone (13)] were isolated from the fruits of Prunus humilis Bunge [Cerasus humilis (Bunge) Sokolov]. Their structures were elucidated based on extensive spectroscopic analysis (including HR-ESI-MS and NMR) and comparison with previously published data. All compounds were evaluated for cytotoxic activity against three human tumour cell lines. Compound 3 and 4 showed weak antiproliferative activities against hepatocarcinoma cell HepG-2 at the concentration of 100 μM, which the inhibition rates were 55.34 ± 0.29 and 45.52 ± 0.37, respectively. And other compounds had almost no cytotoxic activity against the three tumour cell lines in vitro.

Citation

Sheng Dong, Ying Zhou, Ji-Chao Wang, Yi-Lin Zhuo, Yi-Han Sun, Jun-Gang Wang, Guo-Gang Zhang. Four new compounds from the fruits of Chinese dwarf cherry (Prunus humilis Bunge). Natural product research. 2024 Apr;38(7):1207-1215