Hexamethyldisilazane-Mediated Amidination of Sulfonamides and Amines with Formamides.

Hexamethyldisilazane was reacted with formamides to generate N,N-disubstituent formimidamide, after which a reaction with sulfonamides was induced to form sulfonylformamidines. This protocol can be applied for arylformamidine formation in which anilines are used as substrates under optimized conditions. The advantages of this method are high efficiency, structural diversity in products with good yields, and applicability in large-scale operations.

Citation

Yu-Chen Chou, Wei-Han Lin, Xiu-Yi Lin, Chin-Ling Kuo, Wan-Qin Zeng, I-Chung Lu, Chien-Fu Liang. Hexamethyldisilazane-Mediated Amidination of Sulfonamides and Amines with Formamides. The Journal of organic chemistry. 2022 Nov 18;87(22):15327-15332

Mesh Tags

Substances

PMID: 36302512

search → result