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During neurodegenerative disease, resident CNS macrophages termed "microglia" assume a neuroprotective role and engulf toxic protein aggregates and cell debris. In this issue of Cell, two groups independently show how spleen tyrosine kinase (SYK) acts downstream of microglial surface receptors to propagate this neuroprotective program in vivo. Copyright © 2022 Elsevier Inc. All rights reserved.
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Dorothy P Schafer, Jacob M Stillman. Microglia are SYK of Aβ and cell debris. Cell. 2022 Oct 27;185(22):4043-4045
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PMID: 36306731
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