Multisystem inflammatory syndrome in neonates associated with SARS-CoV-2 infection, a different entity?

Multisystemic inflammatory syndrome in children (MIS-C) is a novel disease that is associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). MIS-C usually affects children older than 5 years of age and adolescents, with a median of 8-years and an interquartile range of 3 to 11 years. A multisystemic inflammatory disease has been described in neonates and named MIS-N (multisystemic inflammatory syndrome in Neonates). We report three cases of Mexican newborns with MIS-N presenting with multiorgan compromise and a positive anti-SARS-CoV-2 IgG who developed Kawasaki disease (KD)-like cardiac features and discuss the current dilemma regarding diagnosis and treatment in these patients.

Citation

L B Gámez-González, A S Escárcega-Juárez Ana Silvia, D E Aguilar-Soto, M Colmenero Rascón, A C García Espinosa, M A Yamazaki-Nakashimada. Multisystem inflammatory syndrome in neonates associated with SARS-CoV-2 infection, a different entity? Journal of neonatal-perinatal medicine. 2023;16(1):169-177

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PMID: 36314218

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