Hold the fold: how delayed folding aids protein secretion.

Nicholas McCaul, Ineke Braakman

The EMBO journal 2022 Dec 01

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In bacteria, N-terminal signal peptides mark proteins for transport across the plasma membrane. A recent study by Smets et al (2022) followed the folding of a pair of structural twins to shed light on how evolution has optimised the secretory process. © 2022 The Authors.