Glucagon receptor (GCGR) is an essential regulator of hepatic metabolism. In this issue of Cell Metabolism, Sekar et al. report that the endosomal protein Vps37a uncouples hepatic glucose production from lipid metabolism by altering the intracellular localization of GCGR, thereby providing a new potential therapeutic direction for type 2 diabetes. Copyright © 2022 Elsevier Inc. All rights reserved.
Yan Chen, Dehua Yang, Ming-Wei Wang. An emerging direction in glucagon-based therapy. Cell metabolism. 2022 Nov 01;34(11):1615-1616
PMID: 36323231
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