Elevated IgE from attenuated CARD11 signaling: lessons from atopic mice and humans.

Joel L Pomerantz, Joshua D Milner, Andrew L Snow

Current opinion in immunology 2022 Dec

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CARD11 encodes a large scaffold protein responsible for integrating antigen-receptor engagement with downstream signaling to NF-kB and other outputs in lymphocytes. Over the past 10 years, several human-inborn errors of immunity have been linked to pathogenic CARD11 mutations. Most recently, severe atopic patients were discovered that carried heterozygous dominant-negative CARD11 mutations. Here, we review the mechanistic connections between attenuated CARD11 signaling, elevated IgE, and atopy, comparing and contrasting key insights from both human patients and murine models. Continued investigation of abnormal CARD11 signaling in both contexts should inform novel therapeutic strategies to combat allergic pathogenesis. Published by Elsevier Ltd.

Citation

Joel L Pomerantz, Joshua D Milner, Andrew L Snow. Elevated IgE from attenuated CARD11 signaling: lessons from atopic mice and humans. Current opinion in immunology. 2022 Dec;79:102255