The dual nature of the nucleolus.

The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as "being a multilayered condensate," and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors. © 2022 Tartakoff et al.; Published by Cold Spring Harbor Laboratory Press.

Citation

Alan Tartakoff, Patrick DiMario, Eduard Hurt, Brian McStay, Vikram Govind Panse, David Tollervey. The dual nature of the nucleolus. Genes & development. 2022 Jul 01;36(13-14):765-769

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PMID: 36342833

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