The bromoporphyrins as promising anti-tumor photosensitizers in vitro.

The synthesis of ideal photosensitizers (PSs) is considered to be the most significant bottleneck in photodynamic therapy (PDT). To discover novel PSs with excellent photodynamic anti-tumor activities, a series of novel photosensitizers 5,15-diaryl-10,20-dibromoporphyrins (I1-6) were synthesized by a facile method. Compared with hematoporphyrin monomethyl ether (HMME) as the representative porphyrin-based photosensitizers, it is found that not only the longest absorption wavelength of all compounds was red-shifted to therapeutic window (660 nm) of photodynamic therapy, but also the singlet oxygen quantum yields were significantly increased. Furthermore, all compounds exhibited lower dark toxicity (except I2) and stronger phototoxicity (except I4) against Eca-109 tumor cells than HMME. Among them, I3 possessed the highest singlet oxygen quantum yield (ΦΔ = 0.205), the lower dark toxicity and the strongest phototoxicity (IC50 = 3.5 μM) in vitro. The findings indicated the compounds I3 had the potential to become anti-tumor agents for PDT. © 2022. The Author(s), under exclusive licence to European Photochemistry Association, European Society for Photobiology.

Citation

Man-Yi Li, Le Mi, Tabbisa Namulinda, Yi-Jia Yan, Xing-Ping Zhou, Zhi-Long Chen. The bromoporphyrins as promising anti-tumor photosensitizers in vitro. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023 Feb;22(2):427-439

Mesh Tags

Substances

PMID: 36344865

search → result