Correlation Engine 2.0
Clear Search sequence regions

  • acyl (1)
  • exciton (1)
  • glycosides (3)
  • marsdenia (1)
  • marsdenia tenacissima (2)
  • plant (1)
  • steroid (5)
  • Sizes of these terms reflect their relevance to your search.

    Eleven undescribed glycosylated C21 steroids and nine known homologous glycosides with diverse acyl substituents, as well as their common steroid aglycone, have been obtained from the roots of Marsdenia tenacissima. Their structures were elucidated mainly by comprehensive spectroscopic analyses and comparison with previously reported analogues, with the absolute configuration assignment being supported by chemical degradation, X-ray crystallography and ECD exciton chirality method. Among them, two pairs of regioisomers were found to exist as inseparable equilibrium mixtures due to an interesting intramolecular transesterification, and nicotinoyl substitution was first reported for metabolites from the title plant. Screening of these compounds in a panel of bioassays revealed that two glycosides displayed mild inhibition against butyrylcholinesterase. Copyright © 2022 Elsevier Ltd. All rights reserved.


    Xiu-Qing Song, Lin-Lin Tian, Tao Ye, Hu Liu, Hua Zhang. Steroid glycosides from the roots of Marsdenia tenacissima. Phytochemistry. 2023 Jan;205:113506

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 36347308

    View Full Text