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To report atypical clinical features and diagnosis of stromal herpes simplex keratitis (HSK) and to evaluate the diagnostic efficiency of tear HSV-sIgA in atypical HSK. Prospective observational study. Records of keratitis' patients with tear herpes simplex virus (HSV)-sIgA test results acquired between May 2019 and November 2021 were evaluated retrospectively. Positive tear HSV-sIgA test was used to identify herpes simplex virus (HSV) infection. Patients with typical presentations and histories of HSV keratitis (HSK) were excluded. Eleven eyes of 11 patients initially diagnosed as keratitis caused by other etiology were confirmed as having HSV infection by positive results of tear HSV-sIgA. Clinical features of atypical stromal HSK were variable. Antiviral treatment was effective in all patients. The appearance of an atypical stromal HSK represents a diagnostic challenge. Tear HSV-sIgA test could help provide a quick diagnosis. © 2022. Japanese Ophthalmological Society.


Ji-Ni Qiu, Fei-Fei Huang, Chun-Hong Liu, Wen-Jun Cao, Chao-Ran Zhang. Atypical stromal herpes simplex keratitis: clinical features and diagnosis. Japanese journal of ophthalmology. 2023 Jan;67(1):43-49

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PMID: 36367597

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