Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan.

Lingjun Zhao, Jing Zhao, Zhihao Dong, Shiyuan Xu, Dong Wang

Reproductive toxicology (Elmsford, N.Y.) 2023 Jan

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Busulfan is an alkylating agent commonly used in cancer chemotherapy. It is also an ideal agent for preparing transplant recipients of spermatogonial stem cells because of its high efficiency in destroying endogenous germ cells in the testis. However, its toxicity mechanism remains unclear, affecting its clinical use and applications. Based on reports of busulfan causing orchitis and a previous study by our team, this article summarizes the relationship between busulfan and orchitis, cytokines, the blood-testis barrier, and the cytoskeleton, unravels the regulatory pathways and mechanism behind busulfan-induced orchitis, and reveals the molecular mechanism underlying impaired spermatogenic function in orchitis, providing new ideas for the clinical application of busulfan while reducing its testicular toxicity. Copyright © 2022. Published by Elsevier Inc.

Citation

Lingjun Zhao, Jing Zhao, Zhihao Dong, Shiyuan Xu, Dong Wang. Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan. Reproductive toxicology (Elmsford, N.Y.). 2023 Jan;115:1-7