TRIM11, a new target of p53, facilitates the migration and invasion of nasopharyngeal carcinoma cells.

Ziyi Zhao, Jinkuang Deng, Ming Lu, Jun Yang, Linlin Chen, DianYuan Li, Yi Sang

Molecular biology reports 2023 Jan

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Although tripartite motif-containing protein 11 (TRIM11) is known to be associated with a variety of cancers, its role in nasopharyngeal carcinoma (NPC) is unclear. To investigate the role of TRIM11 in NPC, TRIM11 was stably overexpressed in 6-10B and CNE2 cells with lentiviral vectors and knocked down in S18 and 5-8F cells using the CRISPR/Cas9 system. Transwell assays and wound-healing assays revealed that TRIM11 facilitated the migration and invasion of NPC cells. Mechanistically, we found that p53 inhibits TRIM11 expression by binding to its promoter. TRIM11 may serve as a potential diagnostic marker for NPC and has a certain therapeutic value. © 2022. The Author(s).

Citation

Ziyi Zhao, Jinkuang Deng, Ming Lu, Jun Yang, Linlin Chen, DianYuan Li, Yi Sang. TRIM11, a new target of p53, facilitates the migration and invasion of nasopharyngeal carcinoma cells. Molecular biology reports. 2023 Jan;50(1):731-737