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    In Japan in 2004, 59 people who had consumed angel-wing mushroom, Pleurocybella porrigens, experienced acute encephalopathy, and of these 17 died. We purified a lethal protein to mice, pleurocybelline (PC), from P. porrigens. Although PC caused no damage to the brain, PC formed a complex with a lectin (PPL) and showed exo-protease activity, degrading substrates from both N- and C-termini. In addition, the presence of an unstable toxic compound, pleurocybellaziridine (PA), in the mushroom was demonstrated. We hypothesized that the complex and PA are involved in disease development and verified that apoptotic cells in the hippocampus were significantly increased by injection of the mixture of PC, PPL, and PA, indicating that these substances might be involved in acute encephalopathy. Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.


    Tomohiro Suzuki, Tomohiro Asakawa, Fumihiko Maekawa, Eiki Kimura, Yuki Tezuka, Luna Nakamura, Takumi Sato, Yuto Arai, Jae-Hoon Choi, Masakazu Suzuki, Hideo Dohra, Hirofumi Hirai, Hirokazu Kawagishi. Possible molecular mechanism for acute encephalopathy by angel-wing mushroom ingestion - Involvement of three constituents in onset. Toxicon : official journal of the International Society on Toxinology. 2023 Jan 01;221:106958

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    PMID: 36377137

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