Tian Shi, Weidong Liu, Ting Li, Huan Liu, Wenjia Hui, Qiang Lin, Xiaojiang Han, Feng Gao
Scandinavian journal of gastroenterology 2023 MayCeliac disease (CD) is an autoimmune small bowel disease. Genetic susceptibility for CD is mainly determined by the human leukocyte antigen (HLA)-DQ haplotypes. The risk of CD conferred by HLA genotypes varies geographically and across populations, however, this has not yet been documented in Chinese patients with CD. To investigate the distribution of HLA-DQ and the related risks of CD development in Northwest China. A total of 75 CD patients and 300 healthy individuals were genotyped for HLA-DQ using the Illumina NextSeq, and the relative risks of the different genotypes were evaluated. In total, 68.00% of CD patients and 21.00% of controls carried HLA-DQ2.5 heterodimers (p < 0.001). We identified four CD risk gradients. Individuals carrying a double dose of DQB1*02 had the highest risk of developing CD (1:16); however, with heterozygosis (DQB1*02:02/DQB1*02:01) having the highest risk (1:9). HLA-DQ2.5 individuals with a single copy of HLA-DQB1*02, in either the cis or trans configuration, were at a medium risk (1:38). Non-DQ2.5 carriers of DQ8 or DQ2.2 were at low risk, while only carriers of DQ7.5 or DQX.5 were at very low risk. Patients with the HLA-DQ2.5 genotype had more severe mucosal damage compared with the HLA-DQ2.5 genotype negative CD patients (70.59% vs. 41.67%, p = 0.016). Genetic susceptibility to CD is highly prevalent in the Northwest Chinese population and the highest risk of developing CD was associated with the DQ2.5/DQ2.2 genotype. The DQ2.5 allele is involved in the severity of mucosal injury.
Tian Shi, Weidong Liu, Ting Li, Huan Liu, Wenjia Hui, Qiang Lin, Xiaojiang Han, Feng Gao. HLA-DQ genotype distribution and risk evaluation of celiac disease in Northwest China. Scandinavian journal of gastroenterology. 2023 May;58(5):471-476
PMID: 36415137
View Full Text