Eukaryotic fertilization and gamete fusion at a glance.

In sexually reproducing organisms, the genetic information is transmitted from one generation to the next via the merger of male and female gametes. Gamete fusion is a two-step process involving membrane recognition and apposition through ligand-receptor interactions and lipid mixing mediated by fusion proteins. HAP2 (also known as GCS1) is a bona fide gamete fusogen in flowering plants and protists. In vertebrates, a multitude of surface proteins have been demonstrated to be pivotal for sperm-egg fusion, yet none of them exhibit typical fusogenic features. In this Cell Science at a Glance article and the accompanying poster, we summarize recent advances in the mechanistic understanding of gamete fusion in eukaryotes, with a particular focus on mammalian species. © 2022. Published by The Company of Biologists Ltd.

Citation

Yonggang Lu, Masahito Ikawa. Eukaryotic fertilization and gamete fusion at a glance. Journal of cell science. 2022 Nov 15;135(22)

Mesh Tags

PMID: 36416181

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