MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection.
Se-Jin Kim, Elham Karamooz. MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis. International journal of molecular sciences. 2022 Nov 19;23(22)
PMID: 36430890
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