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This study aimed to investigate associations of serum high-sensitivity C-reactive protein (hsCRP) and social support (SS) levels with suicidal ideation (SI), and to evaluate potential modifying effects of SS on the associations between serum hsCRP levels and SI in two longitudinal cohorts with cardio-/cerebrovascular diseases. 1152 acute coronary syndrome (ACS) and 423 stroke patients were recruited at baseline within 2 weeks of disease onset, and evaluated for: i) serum hsCRP levels; ii) SS by the Social Support Scale and Social Undermining Scale; iii) SI by the "suicidal thoughts" item of the Montgomery-Åsberg Depression Rating Scale; and iv) covariates including socio-demographics, depression, vascular risk factors, and index disease severity. At 12-month follow-up, SI was re-evaluated. Logistic regression models were used to adjust for potential covariates. In the ACS cohort, higher serum hsCRP and lower SS levels were significantly associated with SI at baseline; and only lower SS levels were significantly associated with SI at follow-up. In the stroke cohort, lower SS levels were significantly associated with SI at baseline; but no other association was found. Associations of serum hsCRP levels with SI at both baseline and follow-up were only significant at higher SS levels with significant interaction terms in both cohorts. This study evaluated SI, but not suicide attempts or death; it also used a single-center design. By considering SS evaluations with routine serum hsCRP levels in cardio-/cerebrovascular disease, clinical prediction of SI both at acute and chronic phases of the diseases might be improved. Copyright © 2022 Elsevier B.V. All rights reserved.


Jae-Min Kim, Ju-Wan Kim, Ye-Jin Kim, Hee-Ju Kang, Sung-Wan Kim, Joon-Tae Kim, Man-Seok Park, Jung-Chul Kim, Youngkeun Ahn, Myung Ho Jeong, Robert Stewart. Associations of systemic inflammation and social support with suicidal ideation in patients with acute coronary syndrome and stroke. Journal of affective disorders. 2023 Feb 15;323:101-107

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PMID: 36436762

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