Combined Effect of Ceftriaxon and Low-Frequency Ultrasound on the Viability of Staphylococcus epidermidis Cells in a Preformed Biofilm.

I V Babushkina, I A Mamonova, V Yu Ulyanov, S P Shpinyak

Bulletin of experimental biology and medicine 2022 Nov

filter terms:

We studied the effect of low-frequency ultrasound on the antibacterial effect of ceftriaxone for Staphylococcus epidermidis strains isolated from biomaterial of patients with paraimplant inflammation after total replacement of large joints in the plankton and preformed biofilm forms. Low-frequency ultrasound had no antibacterial effect on the plankton S. epidermidis culture or bacterial cells in the biofilm, and combined exposure of the plankton culture to ultrasound and ceftriaxone did not modulate the antibacterial activity of ceftriaxone. The exposure of the biofilm formed by S. epidermidis strains to low-frequency ultrasound increased the sensitivity of bacterial cells to ceftriaxone in a concentration range of 5-200 μg/ml. © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Citation

I V Babushkina, I A Mamonova, V Yu Ulyanov, S P Shpinyak. Combined Effect of Ceftriaxon and Low-Frequency Ultrasound on the Viability of Staphylococcus epidermidis Cells in a Preformed Biofilm. Bulletin of experimental biology and medicine. 2022 Nov;174(1):47-50